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Oral Administration of LCE
for Psoriasis (Study CT-AE-942-003)

Design of Study:

  • Subjects: 44 subjects (37 men and 12 women), aged 24-75.

  • Status: Moderate to severe psoriasis (Mean PASI score: 10.0 5.6

  • Treatment: Subjects were randomized to one of 3 groups

(30, 60, 120, 240 ml per day)

Study Results:

Number of subjects with PASI Improvement of:

Dose
30 60 120 240
>20 % 0 4 5 6
> 30 % 0 1 2 3
> 50 % 0 0 1 2

Study conclusions:

  • Orally administered LCE are effective in reducing the severity and area of psoriasis

  • The results are proportional to the dose

  • The dose required may be too high for treatment of mild to moderate psoriasis

What about topical application
of LCE?

Copyright 2001